Table 3.
Cox regression analysis of overall and cancer-specific survival in patients with SCRC
| Variable | Overall survival | Cancer specific survival | ||
|---|---|---|---|---|
| AHR (95% CI) | p-value | AHR (95% CI) | p-value | |
| Age (years old) | < 0.001 | < 0.001 | ||
| 20-39 | Reference | Reference | ||
| 40-49 | 1.54(1.18-2.01) | 0.001 | 1.21(0.85-1.72) | 0.298 |
| 50-59 | 2.24(1.75-2.86) | < 0.001 | 1.45(1.05-2.00) | 0.024 |
| 60-69 | 4.07(3.20-5.18) | < 0.001 | 1.97(1.43-2.70) | < 0.001 |
| 70 or older | 10.98(8.65-13.94) | < 0.001 | 4.25(3.11-5.82) | < 0.001 |
| Gender | < 0.001 | < 0.001 | ||
| Male | Reference | Reference | ||
| Female | 0.77(0.75-0.80) | 0.83(0.78-0.88) | ||
| Race | < 0.001 | 0.097 | ||
| White | Reference | Reference | ||
| Black | 1.08(1.02-1.14) | 0.005 | 1.07(0.97-1.18) | 0.160 |
| Asian/Pacific Islander | 0.79(0.74-0.84) | < 0.001 | 0.89(0.79-1.00) | 0.052 |
| American Indian/Alaska Native | 0.86(0.68-1.09) | 0.217 | 1.01(0.68-1.49) | 0.971 |
| Marital status | < 0.001 | < 0.001 | ||
| Married | Reference | Reference | ||
| Unmarried | 1.48(1.42-1.54) | < 0.001 | 1.44(1.34-1.55) | < 0.001 |
| Unknown | 0.47(0.19-1.13) | 0.091 | 0.24(0.03-1.68) | 0.148 |
| Tumor size (cm) | < 0.001 | < 0.001 | ||
| ≤1 | Reference | Reference | ||
| 1-2 | 1.07(1.02-1.13) | 0.003 | 1.19(1.07-1.31) | 0.001 |
| 2-3 | 1.19(1.12-1.25) | < 0.001 | 1.31(1.17-1.47) | < 0.001 |
| 3-4 | 1.32(1.23-1.41) | < 0.001 | 1.65(1.45-1.88) | < 0.001 |
| >4 | 1.36(1.28-1.45) | < 0.001 | 2.04(1.83-2.28) | < 0.001 |
| Unknown | 3.46(1.44-8.35) | 0.006 | 11.48(1.61-81.88) | 0.015 |
| T score | 0.312 | 0.038 | ||
| Tis | Reference | Reference | ||
| T1 | 1.03(0.97-1.09) | 1.12(1.01-1.25) | ||
| Histologic grade | < 0.001 | < 0.001 | ||
| Well differentiated | Reference | Reference | ||
| Moderately differentiated | 1.06(1.01-1.11) | 0.015 | 1.24(1.13-1.37) | < 0.001 |
| Poorly differentiated | 1.21(1.12-1.31) | < 0.001 | 1.62(1.41-1.87) | < 0.001 |
| Undifferentiated | 1.28(1.06-1.53) | 0.009 | 1.47(1.04-2.09) | 0.031 |
| Unknown | 0.47(0.19-1.13) | 0.091 | 0.24(0.03-1.68) | 0.148 |
| Area-level median household income(2022 US dollars) | < 0.001 | < 0.001 | ||
| > 70,000 | Reference | Reference | ||
| < 40,000 | 1.37(1.21-1.56) | < 0.001 | 1.52(1.23-1.88) | < 0.001 |
| 40,000–49,999 | 1.20(1.11-1.30) | < 0.001 | 1.14(0.99-1.31) | 0.078 |
| 50,000–59,999 | 1.26(1.18-1.33) | < 0.001 | 1.28(1.15-1.44) | < 0.001 |
| 60,000–69,999 | 1.15(1.09-1.20) | < 0.001 | 1.23(1.13-1.33) | < 0.001 |
| Population of the residential area | 0.006 | 0.514 | ||
| Urban > 1,000,000 | Reference | Reference | ||
| Urban 250,000–1,000,000 | 1.03(0.99-1.08) | 0.181 | 0.94(0.87-1.02) | 0.161 |
| Urban < 250,000 | 0.91(0.85-0.97) | 0.005 | 0.91(0.81-1.03) | 0.152 |
| Rural adjacent to urban area | 0.95(0.88-1.02) | 0.143 | 0.98(0.86-1.11) | 0.703 |
| Rural not adjacent to urban | 0.99(0.92-1.08) | 0.953 | 0.96(0.83-1.12) | 0.609 |
| Surgical treatment | < 0.001 | < 0.001 | ||
| Yes | Reference | Reference | ||
| No/Unknown | 4.29(4.07-4.51) | 7.85(7.27-8.47) | ||
| Chemotherapy | 0.001 | < 0.001 | ||
| Yes | Reference | Reference | ||
| No/Unknown | 0.84(0.76-0.93) | 0.54(0.48-0.62) | ||
| Radiotherapy | < 0.001 | < 0.001 | ||
| Yes | Reference | Reference | ||
| No/Unknown | 1.34(1.20-1.49) | 1.52(1.32-1.76) | ||