Table 4.

Multivariable logistic regression analysis for steroid timing and dose.

	aOR	95% CI	p-value
Norepinephrine-equivalent dose at first hydrocortisone administration (µg/kg/min)	2.014	1.302–3.114	0.002
Time from first vasopressor to first hydrocortisone administration (h)	1.018	1.003–1.033	0.017
Hydrocortisone dose
Hydrocortisone dose  < 200 mg/day	1.370	0.901–2.086	0.141
Hydrocortisone dose 200–300 mg/day	reference
Hydrocortisone dose  > 300 mg/day	1.577	1.179–2.110	0.002

aOR > 1 indicates higher odds of 28 d mortality.

Each variable of interest was adjusted to a separate multivariable model (primary model)*.

Hosmer–Lemeshow test showed p > 0.05 in all models.

*Sex, admission year, APACHE II score, infection focus, lactate (nearest to initial steroid administration), and use of ≥ 2 types of vasopressors were adjusted.