The size and complexity of the opossum MHC is similar to that of eutherian mammals, but the organization resembles that seen in non-mammals. The Class I and Class II regions are adjacent and somewhat interspersed. The antigen processing genes are closely linked to the Class I genes. The framework region does not contain Class I genes, as it does in eutherians. Like eutherians, the opossum MHC does not contain the third inducible proteasome subunit gene,PSMB10. Some genes present in the human MHC have not been found on the opossum scaffold_42(MAS1L, the histone cluster,C6orf12, HCG2P4, RANP1, C6orf205, C6orf1, DHFRP, HCP5, HCG9P1, PPIP9, LST1, NCR3, AIF1, LY6G5B, LY6G6D, LY6G5E, C6orf10, RPL32P1, PPP1R2P1, HTATSF1P, MYL8P, andLYPLA2P1).