FIG. 1.

Combinations of two pairs of drugs (ketoconazole-cyclopiroxolamine and itraconazole-cyclopiroxolamine) tested with Trichophyton rubrum (ATCC 40051) by use of different methods of inoculum preparation. Full lines represent data obtained with filtered inocula, and dashed lines represent data obtained with nonfiltered inocula. Irregular curves were obtained when unfiltered suspensions were tested. Results obtained with filtered inocula confirm the theoretical synergism for both pairs of drug combinations and exhibited high reproducibility.