FIG. 2.

Calculations using equation A3 of the proportion of cells surviving an isothermal heat treatment in which the probability of critical damage to a critical component is x = 1 −exp(−kt). (a) Plot assuming that all copies of a critical component must be critically damaged for a cell to die (R = 1). The numbers indicate the number of copies per cell (n). The line for n = 1 also represents 1 − x. (b) Plot assuming that no copies of a critical component must be damaged for the cell to survive (R = n). The numbers indicate the number of copies per cell (n). (c) Plot assuming that the total number of copies of the critical component per cell is 100. The number (R) of copies that are not critically damaged per cell is indicated beside each line.