Table 3.
Association of significant risk factors with aspirin and clopidogrel resistance (Logistic regression analysis) in stable CAD patients.
| Predictors of aspirin resistance | ||||||
|---|---|---|---|---|---|---|
| Risk Factors | Univariate logistic regression analysis (n = 151) |
Multivariate logistic regression analysis (n = 144) |
||||
| Odd ratio (± SD) | p value | Odd ratio (± SD) | p value | |||
| Diabetes | 2.2 (1.1–4.4) | 0.03 | 1.4 (0.5-3.8) | 0.52 | ||
| HbA1c | 1.2 (1-1.4) | 0.06 | 1.2 (0.9-1.5) | 0.23 | ||
| VLDL | 1 (0.9-1.1) | 0.96 | 1 (0.9-1.1) | 0.60 | ||
| Clopidogrel resistance | 20.2 (8–50.7) | <0.01 | 20.2 (7.9–51.9) | <0.01 | ||
| Predictors of clopidogrel resistance | ||||||
| Risk Factors |
Univariate logistic regression analysis (n= 144) |
Multivariate logistic regression analysis (n=144) |
||||
|
Odd ratio (± SD) |
p value |
Odd ratio (± SD) |
p value |
|||
| Male sex | 2.1 (0.9-5.1) | 0.88 | 1.1 (0.3-4) | 0.88 | ||
| Family history of CAD | 5.1 (1.5–17.1) | 0.01 | 5.9 (1.4–25.8) | 0.02 | ||
| Diabetes | 1.8 (0.9-3.6) | 0.11 | 1 (0.4-2.8) | 0.93 | ||
| Hemoglobin | 0.8 (0.7–1) | 0.03 | 0.8 (0.6-1) | 0.09 | ||
| ESR | 1 (1–1.1) | 0.03 | 1 (1-1.1) | 0.52 | ||
| Aspirin resistance | 20.2 (8–50.7) | <0.01 | 26.8 (9.4–76.2) | <0.01 | ||
Bold values depict significant parameters (p ≤ 0.05).
CAD= Coronary artery disease, ESR= Erythrocyte sedimentation rate, CI= Confidence interval, VLDL= Very low-density lipoprotein.