Table 3.

NAWM group comparison.

	NAWM Mean intensity			NAWM CoV
	Low EDSS	High EDSS	p-value	Low EDSS	High EDSS	p-value
R1	0.972 ± 0.044	0.956 ± 0.047	0.0081	0.070 ± 0.013	0.076 ± 0.015	0.0027
Unprocessed T1w	53,873.9 ± 6154.9	52,025.8 ± 8156.6	0.0695	0.109 ± 0.008	0.114 ± 0.012	0.0031
Bias-corrected T1w	25,187.8 ± 3084.7	25,610.6 ± 3391.1	0.3218	0.062 ± 0.010	0.072 ± 0.015	1.636E-07 *
Signal modeling	2.155 ± 0.128	2.136 ± 0.107	0.1833	0.062 ± 0.010	0.073 ± 0.015	1.648E-07 *
Linear scaling (fatty tissue)	0.918 ± 0.055	0.905 ± 0.046	0.0344	0.062 ± 0.010	0.072 ± 0.015	1.636E-07 *
Linear scaling (temporal muscle)	2.174 ± 0.160	2.197 ± 0.137	0.1989	0.062 ± 0.010	0.072 ± 0.015	1.636E-07 *

Bold numbers indicate p-values < 0.05, i.e., statistically significant results.

Abbreviations: CoV: coefficient of variation, EDSS: expanded disability status scale, NAWM: normal-appearing white matter, T1w: T1-weighted.

^*remains significant in ANCOVA with age, sex, disease duration, and lesion volume as covariates.