Table III. Genes Upregulated by Inositol.
Description of Experiments are listed in Table I. Negative and positive values indicate downregulation and upregulation, respectively. Expression ratios in boldface indicate ≥ 2-fold difference. Overlapping expression ratios ≤ 2-fold meeting p-value cutoff of 0.025 are listed for comparison.
| Fold Difference
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Expt 1 I+ | Expt 2 C+ | Expt 3 I+C+ (i) | Expt 4 I+C+ (ii) | Expt 5 opi1Δ I+ | Expt 6 opi1Δ I− | Expt 7 control | Description |
| HO* | 2.6 | 3.4 | 4.1 | homothallic switching endonuclease | ||||
| PRY3* | −1.7 | 1.7 | 2.2 | Pathogen Related in Yeast | ||||
| SCW11* | 1.3 | 2.2 | 2.1 | glucan 1,3-beta-glucosidase | ||||
| WSC4* | 2.1 | −2.0 | transmembrane receptor | |||||
| YML131W* | 1.8 | 2.0 | −1.5 | 1.2 | unknown | |||
| AEP2 | 2.1 | ATPase ExPression | ||||||
| AEP3 | −2.2 | ATPase ExPression | ||||||
| AGA1 | 2.7 | −3.2 | cell adhesion molecule binding | |||||
| ARO10 | 1.3 | 2.8 | 2.6 | 1.7 | carboxy-lyase | |||
| BAP3 | 1.5 | 1.5 | 2.0 | −1.5 | amino acid transporter | |||
| BDP1 | 1.4 | −2.1 | transcription factor | |||||
| CDC13 | −2.1 | single-stranded DNA binding | ||||||
| COG4 | 1.3 | 2.0 | 1.7 | Conserved Oligomeric Golgi complex | ||||
| COS111 | −2.0 | Ciclopirox Olamine Sensitive | ||||||
| CUP1-1 | 2.4 | 1.8 | copper ion binding | |||||
| CUP1-2 | 2.3 | 1.8 | copper ion binding | |||||
| CWP1 | 1.9 | 2.0 | structural constituent of cell wall | |||||
| DAL81 | 1.5 | 2.6 | 2.3 | −1.8 | −1.6 | transcription factor | ||
| DSE1 | 1.7 | 1.2 | 3.2 | 3.1 | Daughter Specific Expression | |||
| ELG1 | 1.5 | 2.2 | −1.2 | Enhanced Level of Genomic instability | ||||
| FAR11 | 2.0 | −1.4 | Factor ARrest | |||||
| GCV2 | 1.4 | 2.2 | glycine dehydrogenase (decarboxylating) | |||||
| GLG1 | −2.0 | glycogenin glucosyltransferase | ||||||
| HIR2 | −2.2 | transcription corepressor | ||||||
| IDH1 | 1.6 | 2.1 | 2.5 | −1.5 | isocitrate dehydrogenase (NAD+) | |||
| IDH2 | 1.8 | 2.2 | −1.3 | isocitrate dehydrogenase (NAD+) | ||||
| IMD1 | 1.4 | 2.0 | 2.3 | IMP Dehydrogenase | ||||
| IMD2 | 1.4 | 1.9 | 2.4 | IMP dehydrogenase | ||||
| ISR1 | 1.5 | 2.4 | protein kinase | |||||
| MCD1 | 1.5 | 2.1 | 2.0 | −1.3 | Mitotic Chromosome Determinant | |||
| MCM6 | 2.0 | chromatin binding | ||||||
| MET10 | 1.8 | 2.6 | 2.6 | −1.8 | sulfite reductase (NADPH) | |||
| MET17 | 2.3 | O-acetylhomoserine aminocarboxypropyltransferase | ||||||
| MF(ALPHA)2 | 1.7 | 2.9 | −1.4 | pheromone | ||||
| MGM1 | 1.5 | 2.4 | −1.6 | dynamin GTPase | ||||
| MMT2 | 1.7 | 2.1 | −1.4 | mitochondrial iron accumulation | ||||
| MNT4 | −2.4 | alpha-1,3-mannosyltransferase | ||||||
| MTR10 | 2.1 | 1.9 | −1.4 | −1.5 | nuclear localization sequence binding | |||
| MUC1 | 2.1 | signal transducer | ||||||
| OPT1 | 2.3 | 4.2 | −1.6 | oligopeptide transporter | ||||
| ORC1 | 2.2 | −1.4 | −1.9 | ATPase | ||||
| PIK1 | 1.7 | 2.0 | −1.4 | −1.3 | 1.4 | 1-phosphatidylinositol 4-kinase | ||
| SPC105 | 1.3 | 2.0 | −1.8 | structural constituent of cytoskeleton | ||||
| SST2 | 1.8 | 2.4 | 2.6 | −1.8 | 1.2 | GTPase activator | ||
| SUL2 | 3.3 | sulfate transporter | ||||||
| SUN4 | 2.3 | 3.0 | glucosidase | |||||
| YCR024C | −2.2 | asparagine-tRNA ligase | ||||||
| YNR047W | 2.3 | −1.4 | −1.3 | protein kinase | ||||
| YOL155C | 1.3 | 2.5 | glucosidase | |||||
| YOR022C | −2.2 | phospholipase | ||||||
| YPL137C | 2.1 | 1.9 | unknown | |||||
| YBR168W | 1.9 | 2.5 | −1.3 | −1.6 | 1.4 | unknown | ||
| YLR460C | 3.3 | 2.0 | unknown | |||||
| YBL086C | 2.0 | unknown | ||||||
| YPR097W | 2.0 | −1.5 | −1.6 | 1.5 | unknown | |||
| YNL321W | 1.4 | 1.6 | 1.8 | −2.0 | −1.5 | unknown | ||
| YLR413W | 2.2 | 3.0 | −2.1 | unknown | ||||
| YCR023C | 2.7 | −1.7 | −1.6 | 1.5 | unknown | |||
| YIL169C | −2.0 | unknown | ||||||
*
Swi5p bound genes identifed by Lee et al. (38)