Table 2.

Multivariate linear regression models of the relationship between homocysteine and MMSE score

Model	Subjects <65, Δ in MMSE	p Value	Subjects ≥65, Δ in MMSE	p Value
Model 1*
Continuous (log tHcy)	−1.95 (−3.74, −0.17)	0.032	−3.48 (−4.89, −2.07)	<0.001
Categorical tHcy
50th to 90th %ile (10–15 μmol/L)	−0.23 (−2.86, 2.39)	0.861	−2.56 (−4.21, −0.90)	0.003
>90th %ile (>15 μmol/L)	−1.36 (−3.33, 0.60)	0.173	−3.32 (−4.82, −1.82)	<0.001
Model 2†
Continuous (log tHcy)	0.03 (−1.70, 1.76)	0.970	−2.24 (−3.58, −0.90)	0.001
Categorical tHcy
50th to 90th %ile (10–15 μmol/L)	0.96 (−1.45, 3.37)	0.435	−1.16 (−2.67, 0.36)	0.134
>90th %ile (>15 μmol/L)	0.68 (−1.19, 2.55)	0.474	−1.66 (−3.09, −0.23)	0.023
Model 3‡
Continuous (log tHcy)	−0.0002 (−1.74, 1.74)	0.9998	−2.20 (−3.54, −0.86)	0.001
Categorical tHcy
50th to 90th %ile (10–15 μmol/L)	0.99 (−1.44, 3.41)	0.424	−0.92 (−2.43, 0.59)	0.231
>90th %ile (>15 μmol/L)	0.66 (−1.21, 2.54)	0.489	−1.55 (−2.98, −0.13)	0.033

^*Model 1: continuous = age, creatinine, log tHcy*creatinine; categorical = age, creatinine, categorical tHcy*creatinine.

^†Model 2 = model 1, B-12 deficiency (MMA = 271 nmol/L), sex, race ethnicity, education, Medicaid status.

^‡Model 3 = model 2, hypertension, diabetes, cardiac disease, smoking, ethanol use, body mass index.

tHcy = fasting plasma total homocysteine level; MMSE = Mini Mental State Examination; MMA = methylmalonic acid.