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. Author manuscript; available in PMC: 2006 Jan 27.
Published in final edited form as: Nature. 2005 May 5;435(7038):43–57. doi: 10.1038/nature03481

Figure 4. Phylogeny of gene family members compared to their physical order.

Figure 4

The optimally parsimonious phylogenetic tree of 11 Acetyl-CoA synthase genes , computed using the PHYLIP module 'Protpars' (http://evolution.gs.washington.edu/phylip/doc/protpars.html), is shown to the left; dictyBase ID numbers shown at the end of each branch. The graph (right) indicates the arrangement of these genes on chromosome 2 (solid black boxes; gaps indicate introns, pointed heads indicate direction of transcription; chromosomal distance scale at bottom; other unrelated genes in the same region indicated in grey above the X-axis). The correspondence between phylogeny and physical order implies that the cluster has arisen by a series of segmental tandem duplications and local inversions in parallel with sequence divergence.