Proteins containing repeated EGF/laminin and/or E-set SCOP Superfamily domains are classified into groups containing mannose-6-phosphate receptor, mainly EGF/laminin, mainly E-set, or combinations of domains. Most of these proteins have predicted transmembrane domains and so are expected to be cell surface proteins. ComC, LagC, and LagD are proteins that have been characterized to have adhesion and/or signalling functions during multicellular development73–75. Other domain abbreviations: M-6-P R, mannose-6-phosphate receptor; GFR, growth factor receptor; RNI, RNI-like; Fn 3, fibronectin type III; C2, Calcium-dependent lipid binding; LDL, L domain-like leucine-rich repeat.