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Change (%) from baseline in alveolar diameters induced by VEGFR blockade and ceramide synthesis inhibitors.
| Treatment | VEGF R-inh | Vehicle | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Inhibitor (mg/kg) | PBS | FB1 (2.2) | FB1 (1.1) | Myriocin (1.0) | Myriocin (0.3) | PBS | FB1 (2.2) | FB1 (1.1) | Myriocin (1.0) |
| Mouse | 17.8* | 4.3# | 9.3# | −3.3# | −1.8# | 0 | 12.9* | 4.7 | −1.8 |
| Rat | 21.8* | −2.6# | 17.5* | n/a | n/a | 0 | 9.7* | n/a | n/a |
Abbreviations: n-a not assessed.
p <0.05 versus Vehicle + PBS
p <0.05 versus VEGFR-inh + PBS
