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Postassembly modification of BTA-based supramolecular polymers. (A) Molecular structure of BTA, BTAAlkyne, N₃–Arginine, and BTAClick and a schematic representation of their sequential self-assembly and functionalization. (B) Partial solvent-dependent NMR studies of BTA in binary mixtures of D₂O and MeOH-d ₄ at c = 1 mM and T = 25 °C. (C) Solvent-dependent UV–vis absorption spectra of BTAAlkyne at c = 0.5 mM and T = 25 °C in EtOH (light gray) and in a 5-vol % EtOH aqueous solution. (D) Cryo-TEM micrograph of the supramolecular assemblies of BTAAlkyne formed at c = 0.2 mM in a 5-vol % EtOH aqueous solution. (E) HPLC traces of N₃–Arginine (light gray), BTAAlkyne (dark gray), and the CuAAC reaction mixture (green) with the HR-MS spectrum of the isolated BTAClick shown; the m/z ratio was calculated for the ionized species (M+H+Na+K)³⁺.