Fig. 2.
Vascular differences in patients with non-pCR vs. pCR before therapy. A Analysis of ULM data acquired right before the first NAC cycle. B ULM occurrence maps of primary tumours (outlined in yellow) overlaid on B-mode reference frames. Representative images are shown both for patients with non-pCR (left) and pCR (right). Scale bars: 5 mm. C–I Quantitative ULM features of patients with pCR (filled box; npCR = 8 (original vessel coverage) or 7 (others)∗) and without (unfilled box; nnon-pCR = 12), shown as boxplots with median and interquartile range (IQR). p-values were determined via a two-sided Wilcoxon rank sum test. ∗Patient 16 showed no perfused vessels within the tumour at baseline, preventing the computation of some features. Icons were created using BioRender.