Table 1.
General characteristics of the study population.
| |
With or without pruritus |
|||
|---|---|---|---|---|
| Characteristics | All patients (n = 9,589) | Without pruritus (n = 3,808) | With pruritus (n = 5,781) |
P value |
| Age (years) | 56 (45, 66) | 56.00 (44, 66) | 56 (45, 66) | 0.303 |
| Age group (n, %) | 0.893 | |||
| 18–49 | 3,260 (34.0) | 1,328 (34.9) | 1,932 (33.4) | |
| 50–64 | 3,603 (37.6) | 1,359 (35.7) | 2,244 (38.8) | |
| ≥ 65 | 2,726 (28.4) | 1,121 (29.4) | 1,605 (27.8) | |
| Male (n, %) | 5,761 (60.1) | 2208 (58.0) | 3,553 (61.6) | 0.001 |
| Smoking history (n, %) | 2,308 (24.1) | 772 (20.3) | 1,536 (26.6) | <0.001 |
| Drinking history (n, %) | 1,171 (12.2) | 396 (10.4) | 775 (13.4) | <0.001 |
| Primary disease of end-stage renal disease (n, %) | 0.021 | |||
| Chronic glomerulonephritis | 4,484 (46.8) | 1,846 (48.5) | 2,638 (45.6) | |
| Diabetic nephropathy | 2,170 (22.6) | 826 (21.7) | 1,344 (23.3) | |
| Hypertensive nephropathy | 1,537 (16.0) | 574 (15.1) | 963 (16.7) | |
| Polycystic kidney | 382 (4.0) | 144 (3.8) | 238 (4.1) | |
| Others/Unknown | 1,016 (10.6) | 418 (11.0) | 598 (10.3) | |
| Comorbidities (n, %) Diabetes |
2,751(28.7) | 1,073 (28.2) | 1,678 (29.0) | 0.369 |
| Cardiovascular and cerebrovascular diseases | 4,356 (45.4) | 1,597 (41.9) | 2,759 (47.7) | <0.001 |
| Hyperthyroidism/ hypothyroidism |
1,300 (13.6) | 538 (14.1) | 762 (13.2) | 0.185 |
| Cholestasis | 159 (1.7) | 49 (1.3) | 110 (1.9) | 0.021 |
| Malignancy | 217 (2.3) | 91 (2.4) | 126 (2.2) | 0.498 |
| Dialysis vintage (years) | 3.7 (1.8, 7.3) | 3.3 (1.4, 6.8) | 4.1 (2.0, 7.6) | <0.001 |
| Dialysis modality (n, %) | 0.006 | |||
| Hemodialysis | 8,116 (84.6) | 3,255 (85.5) | 4,861 (84.1) | |
| Peritoneal dialysis | 1,416 (14.8) | 541 (14.2) | 875 (15.1) | |
| Hemodialysis combined with peritoneal dialysis | 57 (0.6) | 12 (0.3) | 45 (0.8) | |
| Hemoglobin (g/L) | 109.0 (98.0,119.0) | 109.0 (98.0,119.0) | 109.0 (98.0,119.0) | 0.513 |
| Eosinophil count (109/L) | 0.19 (0.10,0.34) | 0.17 (0.09,0.31) | 0.20 (0.11,0.36) | <0.001 |
| Albumin (g/l) | 39.00 (36.10,41.80) | 39.00 (36.30,41.80) | 39.05 (36.10,41.70) | 0.600 |
| Alkaline phosphatase (U/L) | 83.00 (65.00,109.75) | 81.00 (63.40,105.00) | 84.00 (65.00,112.00) | <0.0001 |
| Serum calcium (mmol/L) | 2.3 (2.1, 2.4) | 2.3 (2.1, 2.4) | 2.3 (2.1, 2.4) | 0.001 |
| Serum phosphorus (mmol/L) | 1.8 (1.4, 2.2) | 1.7 (1.4, 2.1) | 1.86 (1.5, 2.3) | <0.001 |
| Parathyroid hormone (pg/mL) | 258 (133, 457) | 254 (132,4 36) | 263 (135, 469) | 0.050 |
| CRP (mg/L) | 3.0 (1.2,7.1) | 2.88 (1.1, 6.7) | 3.1 (1.2, 7.6) | 0.000 |
| Creatinine (μmol/L) | 922.2 (729.5,1124.0) | 894.6 (703.0,1086.0) | 942.0 (750.0,1149.0) | <0.001 |
| Dialysis adequacy (urea clearance index Kt/V value) | 1.35 (1.20,1.60) | 1.38 (1.20,1.65) | 1.33 (1.20,1.57) | <0.001 |