Table 4.
GEE analysis of risk factors for CKD-aP (important variables).
| Characteristics | Model I |
Model II |
Model III |
|||
|---|---|---|---|---|---|---|
| OR (95％ CI) | P value | OR (95％ CI) | P value | OR (95％ CI) | P value | |
| Age group, years | ||||||
| 18–49 | Ref | – | Ref | – | Ref | – |
| 50–64 | 1.20 (1.08–1.33) | <0.001 | 1.17 (1.05–1.29) | 0.004 | 1.29 (1.12–1.48) | <0.001 |
| ≥65 | 1.09 (0.97–1.23) | 0.137 | 1.10 (0.97–1.25) | 0.119 | 1.26 (1.07–1.47) | 0.005 |
| Sex (female vs. male) | 0.92 (0.83–1.01) | 0.081 | 0.91 (0.83–1.00) | 0.050 | 0.94 (0.84–1.06) | 0.314 |
| BMI (kg/m2) | 1.00 (0.99–1.01) | 0.858 | 1.00 (0.99–1.02) | 0.679 | 1.00 (0.98– 1.01) | 0.647 |
| Smoking history (yes vs. no) | 1.20 (1.08–1.34) | 0.001 | 1.21 (1.08–1.34) | <0.001 | 1.17 (1.02–1.36) | 0.030 |
| Cardiovascular disease (yes vs. no) | 1.18 (1.06–1.32) | 0.002 | 1.20 (1.04–1.37) | 0.010 | ||
| Hyperthyroidism/hypothyroidism (yes vs. no) | 1.23 (1.04–1.45) | 0.015 | 1.13 (0.92–1.37) | 0.237 | ||
| Dialysis vintage (years) | 1.04 (1.03–1.05) | <0.001 | 1.03 (1.02–1.05) | <0.001 | ||
| Dialysis modality (n, %) | ||||||
| Hemodialysis | Ref | – | Ref | – | ||
| Peritoneal dialysis | 1.46 (1.06–2.01) | 0.021 | 1.46 (0.95–2.24) | 0.082 | ||
| Hemodialysis combined with peritoneal dialysis | 1.96 (1.18–3.25) | 0.009 | 1.74 (0.93–3.24) | 0.081 | ||
| Serum calcium (mmol/L) | 1.38 (1.10–1.73) | 0.006 | ||||
| Serum phosphorus (mmol/L) | 1.27 (1.07–1.51) | 0.008 | ||||
| Creatinine (μmol/L) | 1.00 (1.00–1.00) | 0.004 | ||||
| Dialysis adequacy (urea clearance index Kt/V value) | 0.88 (0.78–0.99) | 0.035 | ||||
CKD-aP, chronic kidney disease (CKD)-associated pruritus. GEE, Generalized estimating equations.