Table 1:
Baseline participant characteristics and imputed peripheral blood cell composition, discovery (CyTOF) cohort.
| Age (mean±SD), years | Sex (%female) | BMI (mean±SD), kg/m2 | Race / Ethnicity | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Caucasian | African-American | Multi-racial | Hispanic/Latino | Baseline radiographic KLG | Baseline WOMAC pain | ||||
| Discovery (CyTOF) cohort | |||||||||
| Healthy controls (HC) (n=12) | 52.8±9.7 | 64% | 35±6 | 100% | 0% | 0 | 1 (9%) | n/a | n/a |
| All OA (n=21) | 59.9±11 | 67% | 30±7 | 95% | 0% | 0 | 1 (5%) | 2±1 | 4.6±3.2 |
| OA radiographic progressors (n=6) | 59.2±10 | 17% | 29±5 | 83% | 0% | 17% | 0 | 2±2 | 4.2±2.9 |
| OA non-radiographic progressors (n=15) | 60.1±11 | 87% | 31±8 | 100% | 0% | 0 | 0 | 2±2 | 4.7±3.3 |
| OA pain progressors (n=6) | 59.9±2.5 | 33% | 31±2 | 100% | 0% | 0 | 1 (7%) | 2±2 | 4.6±0.9 |
| OA non-pain progressors (n=15) | 59.8±6.0 | 73% | 30±2 | 93% | 0% | 7% | 0 | 2±1 | 4.5±1.3 |
| Single cell ATAC-Seq cohort | |||||||||
| HC (n=6) | 50±13 | 17% | 31±6 | 83% | 0% | 13% | 14% | n/a | n/a |
| All OA (n=12) | 53±13 | 59% | 30±6 | 92% | 0% | 8% | 8% | 2±2 | 4.3±3.6 |
| RP (n=6) | 55±13 | 17% | 29±5 | 83% | 0% | 17% | 17% | 2±1 | 4.3±2.8 |
| Non-RP (n=6) | 52±14 | 100% | 31±6 | 100% | 0% | 0% | 0% | 2±1 | 4.5±4.5 |
| Confirmation cohort (DNA methylation imputation) | |||||||||
| HC n=234 | 61±9 | 68% | 29±5 | 86% | 13% | 1% | 0.4% | n/a | n/a |
| All OA n=489 | 62±9 | 64% | 32±6 | 73% | 25% | 2% | 0.4% | 2±1 | 3.5±3.9 |
| RP n=158 | 64±8 | 62% | 33±7 | 71% | 28% | 1% | 1% | 2±1 | 4.4±4.4 |
| PP n=91 | 59±9 | 63% | 31±5 | 70% | 30% | 0% | 1% | 2±1 | 2.8±2.9 |
| Non-RP/PP n=240 | 62±9 | 66% | 31±6 | 76% | 22% | 2% | 0% | 2±1 | 3.2±3.8 |
Values presented in mean±SD. P values by Student t-test (continuous data, normally distributed), Chi square test + Fisher’s exact (categorical data). KLG = -Kellgren Lawrence grade, JSW = joint space width (mm), WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index subscores.