Table 3:
Epigenetic transcriptional accessibility (ATAC-Seq) differences between various OA and control groups
| Cellular subset | #ATAC peaks different at P≤0.01 | #ATAC peaks different at q≤0.05 | #ATAC peaks more accessible in OA | Top 5 genes more accessible in OA | #ATAC peaks less accessible in OA | Top 5 genes less accessible in OA |
|---|---|---|---|---|---|---|
| OA vs. HC | ||||||
| CD8+ memory cells | 516 | 0 | n/a | n/a | n/a | n/a |
| CD4+ regulatory T cells | 1174 | 162 | 6 | ASMT, CCND3, PRAG1, CROCC, PRKX | 156 | LMNL, CHAF1B, FSIP1, GALNT1, KLF6 |
| Monocytes | 1805 | 346 | 272 | CNYP1, GAB2, ADAMTS4, MDM1, MYH9 | 74 | CHAF1B, BCAS1, IFNGR2, LDHA, SCD |
| Basophils | 50 | 0 | n/a | n/a | n/a | n/a |
| Plasmablasts | 329 | 3 | 0 | n/a | 3 | LMNL, AC067752.1, SORL1 |
| Eosinophils | 551 | 0 | n/a | n/a | n/a | n/a |
| MAIT/NKTs | 736 | 3 | 0 | n/a | 3 | CHAF1B, FGD1, TBKBP1 |
| RP vs. NP | ||||||
| CD4+ central memory cells | 387 | 6 | 4 | PRKY, TXLNGY, EIF1AY, DDX3Y | 2 | RP11, ZRSR2 |
| CD8+ central memory cells | 222 | 0 | n/a | n/a | n/a | n/a |
| CD8+ terminal memory cells | 188 | 5 | 5 | PRKY, EIF1AY, DDX3Y, TXLNGY, UTY | 0 | n/a |