Table 2.
Comparison of CD3+CD4+T-cell subset proportions and PBMC miR-155 expression among the three groups (x ± s)
| Parameter | Control group (n = 40) | Non-severe ITP group (n = 44) | Severe ITP group (n = 43) | P value |
|---|---|---|---|---|
| Th1 (%) | 10.96 ± 2.69 | 15.48 ± 3.00* | 20.15 ± 3.25*# | < 0.0001 |
| Th2 (%) | 84.02 ± 4.27 | 74.49 ± 4.11* | 68.44 ± 5.14*# | < 0.0001 |
| Th1/Th2 | 0.13 ± 0.04 | 0.21 ± 0.05* | 0.30 ± 0.07*# | < 0.0001 |
| Th17 (%) | 2.88 ± 1.02 | 5.95 ± 1.04* | 7.74 ± 1.59*# | < 0.0001 |
| Treg (%) | 8.02 ± 1.10 | 7.14 ± 1.13* | 6.47 ± 1.19*# | < 0.0001 |
| Th17/Treg | 0.37 ± 0.15 | 0.84 ± 0.18* | 1.24 ± 0.35*# | < 0.0001 |
| miR-155 | 0.81 ± 0.20 | 3.71 ± 0.91* | 5.56 ± 1.08*# | < 0.0001 |
Th1, Th2, Th17, and Treg values are expressed as percentages of gated CD3+CD4+ T cells
*P<0.05 vs. control group; # P<0.05 vs. non-severe ITP group