TABLE 2.
In vitro efficacy of pinensins in restoring the susceptibility of 30 Enterobacterales strains producing VIM, NDM, or IMP type MβLs to meropenem expressed as MIC percentilesb
| Isolates | No pinensin | 15 μM Pinensin A | 15 μM Pinensin B | ||||||
|---|---|---|---|---|---|---|---|---|---|
| MIC50 | MIC75 | MIC90 | MIC50 | MIC75 | MIC90 | MIC50 | MIC75 | MIC90 | |
| All (n = 30) | 8 | 12 | 64 | 0.25 | 0.25 | 1 | 0.25 | 0.25 | 1 |
| VIM (n = 10)a | 4 | 64 | 128 | 0.25 | 0.25 | 0.5 | 0.25 | 0.25 | 0.5 |
| NDM (n = 10) | 8 | 16 | 128 | 0.25 | 0.5 | 8 | 0.25 | 1 | 8 |
| IMP (n = 10) | 4 | 8 | 8 | 0.25 | 0.5 | 2 | 0.25 | 0.5 | 2 |
a
One strain included in the VIM group co-produced the NDM-1 ΜβL.
b
Calculated in GraphPad’s Prism v8 as median values.