Table 4.
Incremental predictive performance of insulin resistance-related indices for cardiometabolic multimorbidity in participants with MASLD
| Model | C-index | NRI | IDI | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate | 95% CI | P value | Estimate | 95% CI | P value | Estimate | 95% CI | P value | |
| Conventional model (Reference) | 0.755 | 0.749–0.762 | – | Ref | – | – | Ref | – | – |
| Conventional model + TyG | 0.764 | 0.757–0.770 | < 0.001 | 0.098 | 0.066–0.128 | < 0.001 | 0.009 | 0.005–0.013 | < 0.001 |
| Conventional model + TyG-BMI | 0.769 | 0.762–0.775 | < 0.001 | 0.151 | 0.124–0.174 | < 0.001 | 0.017 | 0.011–0.022 | < 0.001 |
| Conventional model + TyG-WC | 0.771 | 0.765–0.778 | < 0.001 | 0.163 | 0.140–0.183 | < 0.001 | 0.021 | 0.016–0.027 | < 0.001 |
| Conventional model + TyG-WHtR | 0.773 | 0.767–0.779 | < 0.001 | 0.169 | 0.115–0.181 | < 0.001 | 0.022 | 0.013–0.027 | < 0.001 |
| Conventional model + TyG-BRI | 0.769 | 0.762–0.775 | < 0.001 | 0.143 | 0.114–0.179 | < 0.001 | 0.016 | 0.011–0.022 | < 0.001 |
| Conventional model + TyG-ABSI | 0.763 | 0.756–0.769 | < 0.001 | 0.099 | 0.069–0.119 | < 0.001 | 0.009 | 0.006–0.012 | < 0.001 |
| Conventional model + TyG-VAI | 0.760 | 0.754–0.767 | < 0.001 | 0.055 | 0.034–0.085 | < 0.001 | 0.004 | 0.001–0.006 | < 0.001 |
| Conventional model + TyG-WWI | 0.768 | 0.762–0.775 | < 0.001 | 0.131 | 0.077–0.150 | < 0.001 | 0.015 | 0.007–0.018 | < 0.001 |
| Conventional model + TG/HDL-C ratio | 0.760 | 0.753–0.766 | < 0.001 | 0.055 | 0.012–0.079 | < 0.001 | 0.003 | 0.001–0.005 | < 0.001 |
Conventional models were adjusted for age, sex, ethnicity, educational levels, Townsend deprivation index, frequency of drinking, smoking status, physical activity, self-reported history of hypertension, self-reported history of cancer, use of lipid-lowering medication, use of antihypertensive medication, and family history of cardiometabolic disease
CMM, cardiometabolic multimorbidity; NRI, net reclassification improvement; IDI, integrated discrimination improvement; CI, confidence interval; TyG, triglyceride-glucose index; BMI, body mass index; WC, waist circumference; WHtR, waist-to-height ratio; BRI, body roundness index; ABSI, a body shape index; VAI, visceral adiposity index; WWI, weight-adjusted waist index; TG/HDL-C, triglyceride-to-high-density lipoprotein cholesterol ratio