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. 2026 Sep 3;16:27560. doi: 10.1038/s41598-026-57340-5

Table 3.

Association between ACTN3 R577X genotype and sarcopenia stratified by sex.

Crude- β (95% CI) p-value Adj-βa (95% CI) p-value Crude-β (95% CI) p-value Adj-βa (95% CI) p-value
SMMI (Kg/m2)
RR + RX Ref Ref Ref Ref
XX  − 0.12 (− 0.36 ~ 0.12) 0.322  − 0.02 (− 0.19 ~ 0.15) 0.835 0.02 (− 0.16 ~ 0.19) 0.865 0.02 (− 0.11 ~ 0.15) 0.799
Grip strength (Kg)
RR + RX Ref Ref Ref Ref
XX  − 0.15 (− 2.83 ~ 2.53) 0.910  − 0.17 (− 2.65 ~ 2.31) 0.895 1.24 (− 0.18 ~ 2.65) 0.089 1.24 (− 0.11 ~ 2.58) 0.072
Gait speed (Meters/sec)
RR + RX Ref Ref Ref Ref
XX 0.01 (− 0.10 ~ 0.11) 0.902  − 0.01 (− 0.12 ~ 0.09) 0.789 0.02 (− 0.06 ~ 0.10) 0.604 0.03 (− 0.05 ~ 0.10) 0.519
Five-time chair stand time (Sec)
RR + RX Ref Ref Ref Ref
XX  − 0.43 (− 2.00 ~ 1.13) 0.589  − 0.28 (− 1.78 ~ 1.22) 0.712 0.09 (− 1.34 ~ 1.52) 0.900 0.06 (− 1.30 − 1.43) 0.927

For binary outcomes (sarcopenia), odds ratios (OR) with 95% CI are reported, regression coefficients (β) with 95% confidence intervals (CI) are shown.

For continuous outcomes (SMMI, grip strength, gait speed, and five-time chair stand time).

aAll result of Adj-beta were adjusted by age, BMI.