Table 5.
Interaction of ACTN3 R577X and physical activity on sarcopenia stratified by sex.
| Sarcopenia components /Genotype |
Men | Women | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Crude-OR (95% CI) |
p-value | Adj- ORa (95% CI) |
p-value | Interaction p-value | Crude- OR (95% CI) |
p-value | Adj- ORa (95% CI) |
p-value | Interaction p-value | |
| Sarcopenia b | 0.093 | 0.794 | ||||||||
| RR + RX | 0.46 (0.26 ~ 0.81) | 0.031b | 0.42 (0.18 ~ 0.95) | 0.092 | 1.09 (0.63 ~ 1.89) | 0.758 | 1.08 (0.59 ~ 1.97) | 0.800 | ||
| XX | 0.32 (0.08 ~ 1.29) | 0.110 | 0.30 (0.06 ~ 1.27) | 0.109 | 0.77 (0.21 ~ 2.78) | 0.687 | 0.53 (0.03 ~ 9.19) | 0.660 | ||
| Crude-β (95% CI) | p-value | Adj- βa (95% CI) | p-value | Interaction p-value | Crude- β (95% CI) | p-value | Adj- βa (95% CI) | p-value | Interaction p-value | |
|---|---|---|---|---|---|---|---|---|---|---|
| SMMI (Kg/m2) | 0.153 | 0.388 | ||||||||
| RR + RX | 0.12 (0.01 ~ 0.23) | 0.045b | 0.06 ( − 0.05 ~ 0.17) | 0.282 | 0.01 ( − 0.08 ~ 0.09) | 0.939 | 0.00 ( − 0.09 ~ 0.09) | 0.996 | ||
| XX | 0.20 ( − 0.05 ~ 0.45) | 0.105 | 0.24 ( − 0.00 ~ 0.49) | 0.053 | − 0.12 ( − 0.38 ~ 0.13) | 0.335 | − 0.14 ( − 0.38 ~ 0.11) | 0.276 | ||
| Grip strength (Kg) | 0.528 | 0.588 | ||||||||
| RR + RX | 1.54 (0.34 ~ 2.74) | 0.007b | 0.50 ( − 0.65 ~ 1.66) | 0.270 | 0.79 (0.09 ~ 1.49) | 0.023b | 0.70 ( − 0.01 ~ 1.40) | 0.066 | ||
| XX | − 0.69 ( − 3.14 ~ 1.27) | 0.571 | − 0.48 ( − 2.88 ~ 1.92) | 0.648 | 1.04 ( − 0.86 ~ 2.94) | 0.285 | 1.55 ( − 0.34 ~ 3.44) | 0.103 | ||
| Gait speed (Meters/sec) | 0.412 | 0.021b | ||||||||
| RR + RX | 0.11 (0.06 ~ 0.16) | < 0.001b | 0.08 (0.03 ~ 0.13) | 0.001b | 0.07 (0.03 ~ 0.11) | < 0.001b | 0.07 (0.03 ~ 0.10) | 0.002b | ||
| XX | 0.02 ( − 0.06 ~ 0.10) | 0.596 | 0.04 ( − 0.03 ~ 0.10) | 0.300 | − 0.05 ( − 0.15 ~ 0.05) | 0.286 | − 0.06 ( − 0.16 ~ 0.04) | 0.181 | ||
| Five-time chair stand time (sec) | 0.113 | 0.005b | ||||||||
| RR + RX | − 1.39 ( − 2.08 ~ − 0.70) | < 0.001b | − 1.31 ( − 1.94 ~ − 0.70) | 0.008b | − 0.90 ( − 1.58 ~ − 0.21) | < 0.001b | − 1.13 ( − 1.74 ~ − 0.54) | 0.001b | ||
| XX | 0.44 ( − 0.94 ~ 1.81) | 0.524 | 1.14 ( − 0.55 ~ 2.82) | 0.413 | 0.43 ( − 0.77 ~ 1.63) | 0.182 | 1.33 ( − 0.40 ~ 3.06) | 0.133 | ||
Physical activity was expressed as MET-minutes/week. Odds ratios (ORs) and 95% confidence intervals (CIs) were expressed per 500 MET-minutes/week. Beta coefficients and 95% CIs were also expressed per 500 MET-minutes/week.
a All result of Adj-beta were adjusted by age, BMI.
b p < 0.05.