Table 2.
Tyrosinase inhibitory activity of structural optimization compounds.
| Compound | Structure | IC50 value ± SD (μM, n = 3) |
|
|---|---|---|---|
| L-dopa | L-tyrosine | ||
| V |  |
41.8 ± 3.0 | 11.9 ± 0.5 |
| V-1 |  |
> 800 | 204.0 ± 3.9 |
| V-2 |  |
> 400 | 294.9 ± 24.2 |
| V-3 |  |
66.1 ± 4.6 | 60.6 ± 4.5 |
| V-4 |  |
26.1 ± 4.6 | 2.9 ± 0.1 |
| V-5 |  |
> 200 | 147.6 ± 25.4 |
| V-6 |  |
296.1 ± 7.9 | 88.9 ± 2.9 |
| V-7 |  |
119.1 ± 5.2 | 25.8 ± 1.1 |
| V-8 |  |
> 800 | 298.2 ± 16.6 |
| V-9 |  |
> 800 | 328.2 ± 4.9 |
| V-10 |  |
19.0 ± 2.2 | 7.4 ± 0.4 |
| V-11 |  |
> 400 | 20.1 ± 0.7 |
| V-12 |  |
> 800 | > 800 |
| V-13 |  |
103.3 ± 5.6 | 131.8 ± 5.4 |
| V-14 |  |
72.6 ± 3.1 | 83.2 ± 3.2 |
| V-15 |  |
140.0 ± 15.6 | 41.8 ± 3.2 |
| V-16 |  |
> 800 | > 300 |
| V-17 |  |
> 800 | > 600 |
| V-18 |  |
> 800 | > 300 |
| V-19 |  |
> 800 | > 600 |
| V-20 |  |
21.3 ± 0.8 | 9.1 ± 0.6 |
| V-21 |  |
21.0 ± 0.82 | 8.2 ± 0.4 |
| V-22 |  |
0.085 ± 0.016 | 0.122 ± 0.008 |
| V-23 |  |
0.134 ± 0.008 | 0.183 ± 0.013 |
| V-24 |  |
0.018 ± 0.0007 | 0.020 ± 0.001 |
| V-25 |  |
0.147 ± 0.013 | 0.165 ± 0.008 |
| V-26 |  |
0.020 ± 0.002 | 0.023 ± 0.002 |
| V-27 |  |
0.596 ± 0.026 | 0.497 ± 0.070 |
| V-28 |  |
0.019 ± 0.0002 | 0.021 ± 0.001 |
| V-29 |  |
0.189 ± 0.005 | 0.216 ± 0.019 |
| V-30 |  |
0.022 ± 0.001 | 0.021 ± 0.0003 |
| V-31 |  |
0.153 ± 0.011 | 0.187 ± 0.003 |
| V-32 |  |
0.021 ± 0.002 | 0.024 ± 0.002 |
| V-33 |  |
0.237 ± 0.011 | 0.299 ± 0.007 |
| V-34 |  |
0.032 ± 0.004 | 0.041 ± 0.005 |
| kojic acid |  |
40.3 ± 2.9 | 20.8 ± 0.6 |