Table 1.
Patient characteristics and laboratory findings.
| Period I | Period II | p-value | |
|---|---|---|---|
| (2009/1 to 2019/12) | (2020/1 to 2024/2) | ||
| Variables | N = 510 | N = 367 | |
| Sex (M/F) | 334/176 | 261/106 | 0.078 |
| Age (years) | 73.3 ± 0.5 | 70.8 ± 0.6 | <0.001 |
| Clinical diagnosis (N, %) | <0.001 | ||
| Stable angina | 129 (25.3) | 166 (45.2) | |
| Unstable angina | 170 (33.3) | 71 (19.3) | |
| NSTEMI | 116 (22.7) | 62 (16.9) | |
| STEMI | 25 (4.9) | 14 (3.8) | |
| Ischemic CM | 70 (13.7) | 54 (14.7) | |
| Cardiogenic shock | 26 (5.1) | 14 (3.8) | 0.368 |
| Hypertension (N, %) | 323 (63.3) | 163 (44.4) | <0.001 |
| Diabetes (N, %) | 286 (56.1) | 167 (45.5) | 0.002 |
| Dyslipidemia (N,%) | 158 (31.0) | 97 (26.4) | 0.143 |
| PAD (N, %) | 46 (9.0) | 23 (6.3) | 0.135 |
| CKD (N, %) | 162 (31.8) | 105 (28.6) | 0.317 |
| Af/AF (N, %) | 29 (5.7) | 27 (7.4) | 0.318 |
| History of CABG (N,%) | 52 (10.2) | 50 (13.6) | 0.118 |
| Baseline LVEF (%) | 46.2 ± 0.7 | 46.7 ± 0.8 | 0.604 |
| Lab data | |||
| Hemoglobin (mg/dL) | 11.2 ± 0.1 | 11.7 ± 0.1 | < 0.001 |
| BUN (mg/dL) | 28 (6–124) | 27 (5–143) | 0.925 |
| CR (mg/dL) | 1.3 (0.3–15.6) | 1.4 (0.5–14.8) | 0.397 |
| EPI-eGFR (mL/min) | 50.4 (3.4–111.2) | 49.8 (3.4–158.4) | 0.753 |
| HDL-chol (mg/dL) | 44.0 ± 0.7 | 44.4 ± 0.9 | 0.689 |
| LDL-chol (mg/dL) | 82.9 ± 1.6 | 74.6 ± 1.9 | < 0.001 |
| FBS (mg/dL) | 150 ± 5 | 149 ± 5 | 0.855 |
| HbA1c (mg/dL) | 6.7 ± 0.1 | 6.7 ± 0.1 | 0.960 |
| Total CK (U/L) | 255 ± 38 | 223 ± 28 | 0.528 |
| CK-MB (U/L) | 14.6 ± 2.1 | 9.6 ± 0.9 | 0.028 |
| Troponin-T (ng/mL) | 40.2 (0.0–10,000) | 57.6 (4.0–8,240) | 0.457 |
| CAD vessel numbers | |||
| SVD (N, %) | 181 (35.5) | 87 (23.7) | <0.001 |
| DVD (N, %) | 139 (27.3) | 140 (38.1) | |
| TVD (N, %) | 190 (37.3) | 140 (38.1) | |
| LM (N, %) | 68 (13.3) | 33 (9.0) | 0.047 |
| Isolated | 0 | 4 (1.1) | |
| Plus | 68 (13.3) | 29 (7.9) |
Continuous variables are expressed as mean ± SEM; BUN, Cr, EPI-eGFR, and troponin-T are expressed as median (range). Af/AF, atrial fibrillation or flutter; CABG, coronary artery bypass grafting; CAD, coronary artery disease; CM, cardiomyopathy; CR, creatinine; CKD, chronic renal disease; DVD, double-vessel disease; ESRD, end-stage renal disease; FBS, fasting blood sugar; LM, left main coronary artery; LVEF, left ventricular ejection fraction; NSTEMI, non-ST elevation myocardial infarction; PAD, peripheral artery disease; STEMI, ST-elevation myocardial infarction; SVD, single-vessel disease; TVD, triple-vessel disease.