. Author manuscript; available in PMC: 2026 Sep 5.

Published before final editing as: J Acad Nutr Diet. 2026 Aug 19:156830. doi: 10.1016/j.jand.2026.156830

Table 3:

Spearman correlations between percent energy from fat, inflammation, circulating tumor cells, and circulating tumor DNA in the Exercise and Colorectal Cancer Treatment (EXACT) trial (N=57)

Soluble factor	Percent energy from fat
	Unadjusted		Adjusted (age, sex, race, cancer stage, MVPA^a)		Fully adjusted (age, sex, race, cancer stage, MVPA^a, VAT^b)
	r	95% CI	r	95% CI	r	95% CI
High-sensitivity c-reactive protein (hsCRP) (mg/L)	−0.04	−0.30-0.22	−0.007	−0.32-0.29	0.006	−0.32-0.31
Interleukin-6 (IL-6) (pg/mL)^c	0.19	−0.09-0.43	0.16	−0.17-0.45	0.12	−0.21-0.46
Soluble interleukin-6 receptor (sIL-6r) (pg/mL)^d	0.32	0.06-0.53	0.26	−0.03-0.51	0.24	−0.04-0.50
Tumor necrosis factor alpha (TNFα) (pg/mL)^e	0.23	−0.04-0.46	0.16	−0.14-0.42	0.06	−0.23-0.35
Soluble tumor necrosis factor alpha receptor 1 (sTNFr1) (pg/mL)^f	0.32	0.06-0.53	0.25	−0.009-0.48	0.20	−0.07-0.44
Soluble tumor necrosis factor alpha receptor 2 (sTNFr2) (pg/mL)^g	0.34	0.09-0.55	0.32	0.06-0.55	0.28	0.02-0.51
Interleukin-2 (IL-2) (pg/mL)^h	0.15	−0.15-0.42	0.04	−0.26-0.35	0.001	−0.29-0.33
Soluble interleukin-2 receptor alpha (sIL-2rα) (pg/mL)ⁱ	0.29	0.03-0.51	0.24	−0.03-0.47	0.20	−0.05-0.42
Interleukin-10 (IL-10) (pg/mL)^j	−0.01	−0.27-0.25	−0.02	−0.30-0.28	−0.08	−0.37-0.23
Interleukin-23 (IL-23)(pg/mL)^k	−0.08	−0.33-0.18	−0.11	−0.39-0.21	−0.17	−0.44-0.15
Soluble receptor for advanced glycation end-products (sRAGE) (pg/mL)^l	0.23	−0.07-0.48	0.25	−0.09-0.53	0.22	−0.10-0.51
Circulating tumor cells (CTCs) (cells/mL)	0.19	−0.09-0.43	0.22	−0.03-0.46	0.22	−0.03-0.47
Circulating tumor DNA (ctDNA) (%)	−0.03	−0.29-0.24	−0.01	−0.32-0.30	−0.02	−0.34-0.29

Moderate-to-vigorous physical activity

Visceral adipose tissue

To convert pg/mL interleukin-6 to pmol/L, multiply by 0.0481

To convert pg/mL soluble interleukin-6 receptor to pmol/L, multiply by 0.0237

To convert pg/mL tumor necrosis factor alpha to pmol/L, multiply by 0.0575

To convert pg/mL soluble tumor necrosis factor alpha receptor 1 to pmol/L, multiply by 0.0182

To convert pg/mL soluble tumor necrosis factor alpha receptor 2 to pmol/L, multiply by 0.0133

To convert pg/mL interleukin-2 to pmol/L, multiply by 0.0667

ⁱ

To convert pg/mL soluble interleukin-2 receptor alpha to pmol/L, multiply by 0.0403

To convert pg/mL interleukin-10 to pmol/L, multiply by 0.0556

To convert pg/mL interleukin-23 to pmol/L, multiply by 0.0169

To convert pg/mL soluble receptor for advanced glycation end-products to pmol/L, multiply by 0.0294