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. 2026 Aug 24;17:1691999. doi: 10.3389/fphar.2026.1691999

FIGURE 8.

Infographic illustrating curcumin's effects on various fibrotic and inflammatory diseases, showing molecular pathways, cell interactions, and physiological outcomes in orbital fibroblasts, spinal cord injury, epidural fibrosis, PAD, peritoneal fibrosis, and polycystic ovary syndrome, accompanied by diagrams of tissues, signaling molecules, and a central curcumin molecule.

Antifibrotic role of curcumin (CUR) in other system fibrosis. CUR modulates key signaling molecules and downregulates pro-fibrotic and pro-inflammatory factors. In different pathological settings, CUR reduces macrophage/neutrophil infiltration, fibroblast activation, and fibrosis while improving functional outcomes such as tube-forming capacity, migratory ability, antiangiogenic effect, average myotube diameter, total running time, running capacity, and follicle count. (A) Orbital fibrosis; (B) Spinal cord injury; (C) Peripheral arterial disease; (D) Muscle fibrosis; (E) Polycystic ovary syndrome; (F) Peritoneal fibrosis.