Table 3.

Association of cannabis use in teenagers with later depression and anxiety in 1601 young adults in wave 7 of the Victorian adolescent health cohort study

Measures in waves 1-6	No*	Unadjusted odds ratio (95% CI)	Adjusted odds ratio (95% CI)†
Depression and anxiety (at least one wave)	744	6 (4.3 to 8.4)	5.1 (3.6 to 7.3)
Maximal cannabis use
None	1083	1	1
<Weekly	332	1.5 (1.1 to 2.1)	1.4 (94 to 2.0)
>Weekly‡:
Male teenagers	108	0.62 (0.24 to 1.6)	0.47 (0.17 to 1.3)
Female teenagers	78	2.6 (1.6 to 4.3)	1.9 (1.1 to 3.3)
Female sex in the absence of >weekly cannabis use	788	2.3 (1.6 to 3.1)	1.6 (1.1 to 2.3)

^*Numbers for adolescent cannabis use and depression and anxiety were estimated from five imputed datasets. 

^†Odds ratios by the highest frequency of cannabis use in teenagers (waves 1 to 6), obtained by using a multivariate logistic model, adjusted for teenagers' depression and anxiety, alcohol use, antisocial behaviour, parental separation, and parental education. 

^‡Wald test for interaction between more frequent than weekly cannabis use and sex: unadjusted P<0.001, adjusted P=0.011.