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. 2026 Mar 2;34(9):1374–1383. doi: 10.1038/s41431-026-02040-x

Table 2.

Multivariable logistic regression assessing predictors of clinician confidence across four CPS-related domains.

Genetic work-up (i) Utilising somatic genetic information (ii) Utilising germline genetic information (iii) Counselling Families (iv)
Predictor OR (95%-CI) p OR (95%-CI) p OR (95%-CI) p OR (95%-CI) p
Sex (female) 1.42 (0.72–2.83) 0.31 1.57 (0.84–2.95) 0.16 1.33 (0.71–2.49) 0.38 0.79 (0.4–1.51) 0.47
≥10 years of experience 1.51 (0.78–2.94) 0.22 1.11 (0.6–2.05) 0.74 0.67 (0.36–1.24) 0.2 1.17 (0.61–2.25) 0.63
Access to a paediatric geneticist 2.99 (1.35–6.89) 0.0080* 2.53 (1.17–5.78) 0.022* 1.85 (0.85–4.24) 0.13 1.6 (0.71–3.84) 0.27
Access to a dedicated CPS clinic 2.78 (1.42–5.53) 0.0031* 1.35 (0.72–2.56) 0.35 1.37 (0.73–2.61) 0.33 0.88 (0.45–1.72) 0.71

CI confidence interval, CPS Cancer Predisposition Syndrome, OR odds ratio.