Table 4.
Cox regression analysis of baseline IR markers and cardiovascular disease risk based on CHARLS data
| Variables | Model1 | Model2 | Model3 | |||
|---|---|---|---|---|---|---|
| HR(95%CI) | P | HR(95%CI) | P | HR(95%CI) | P | |
| TyG | 1.2(1.11, 1.30) | < 0.001 | 1.21(1.12, 1.31) | < 0.001 | 1.2(1.11, 1.30) | < 0.001 |
| TyG tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.22(1.09, 1.37) | < 0.001 | 1.22(1.09, 1.37) | < 0.001 | 1.21(1.07, 1.35) | 0.001 |
| Q3 | 1.27(1.14, 1.42) | < 0.001 | 1.27(1.13, 1.42) | < 0.001 | 1.26(1.13, 1.41) | < 0.001 |
| P for trend | 1.19(1.09, 1.28) | < 0.001 | 1.18(1.09, 1.28) | < 0.001 | 1.18(1.09, 1.28) | < 0.001 |
| TyG-WC | 1(1.00, 1.00) | < 0.001 | 1(1.00, 1.00) | < 0.001 | 1(1.00, 1.00) | < 0.001 |
| TyG-WC tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.12(1.00, 1.26) | 0.055 | 1.13(1.00, 1.27) | 0.049 | 1.13(1.00, 1.27) | 0.052 |
| Q3 | 1.48(1.32, 1.65) | < 0.001 | 1.49(1.33, 1.66) | < 0.001 | 1.5(1.33, 1.68) | < 0.001 |
| P for trend | 1.32(1.22, 1.43) | < 0.001 | 1.32(1.22, 1.43) | < 0.001 | 1.33(1.22, 1.44) | < 0.001 |
| TyG-WWI | 1.02(1.01, 1.02) | < 0.001 | 1.01(1.00, 1.01) | < 0.001 | 1.01(1.00, 1.01) | < 0.001 |
| TyG-WWI tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.21(1.08, 1.36) | 0.001 | 1.14(1.02, 1.29) | 0.025 | 1.12(1.00, 1.27) | 0.053 |
| Q3 | 1.41(1.26, 1.58) | < 0.001 | 1.24(1.10, 1.40) | < 0.001 | 1.2(1.07, 1.36) | 0.003 |
| P for trend | 1.28(1.18, 1.38) | < 0.001 | 1.16(1.07, 1.27) | < 0.001 | 1.14(1.05, 1.24) | 0.002 |
| TyG-BMI | 1.01(1.00, 1.01) | < 0.001 | 1.01(1.00, 1.01) | < 0.001 | 1.01(1.00, 1.01) | < 0.001 |
| TyG-BMI tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.1(0.98, 1.23) | 0.117 | 1.15(1.02, 1.29) | 0.022 | 1.16(1.03, 1.30) | 0.013 |
| Q3 | 1.25(1.12, 1.40) | < 0.001 | 1.31(1.17, 1.47) | < 0.001 | 1.31(1.17, 1.47) | < 0.001 |
| P for trend | 1.17(1.08, 1.27) | < 0.001 | 1.21(1.12, 1.31) | < 0.001 | 1.21(1.12, 1.31) | < 0.001 |
| TyG-ABSI | 6.1(3.98,9.34) | < 0.001 | 5.08(3.26,7.93) | < 0.001 | 4.93(3.14,7.75) | < 0.001 |
| TyG-ABSI tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.13(1.01, 1.28) | 0.035 | 1.09(0.96, 1.22) | 0.172 | 1.08(0.96, 1.22) | 0.189 |
| Q3 | 1.47(1.31, 1.64) | < 0.001 | 1.39(1.24, 1.56) | < 0.001 | 1.38(1.23, 1.55) | < 0.001 |
| P for trend | 1.31(1.21, 1.42) | < 0.001 | 1.26(1.16, 1.37) | < 0.001 | 1.25(1.15, 1.36) | < 0.001 |
| TyG-BRI | 1.02(1.01, 1.02) | < 0.001 | 1.01(1.01, 1.02) | < 0.001 | 1.01(1.01, 1.02) | < 0.001 |
| TyG-BRI tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.26(1.12, 1.42) | < 0.001 | 1.25(1.11, 1.41) | < 0.001 | 1.24(1.10, 1.40) | < 0.001 |
| Q3 | 1.54(1.38, 1.73) | < 0.001 | 1.47(1.30, 1.65) | < 0.001 | 1.44(1.28, 1.63) | < 0.001 |
| P for trend | 1.36(1.26, 1.47) | < 0.001 | 1.31(1.20, 1.43) | < 0.001 | 1.29(1.19, 1.41) | < 0.001 |
| TyG-WHtR | 1.3(1.22, 1.39) | < 0.001 | 1.27(1.19, 1.36) | < 0.001 | 1.26(1.18, 1.35) | < 0.001 |
| TyG-WHtR tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.2(1.07, 1.35) | 0.002 | 1.19(1.05, 1.34) | 0.005 | 1.18(1.05, 1.33) | 0.006 |
| Q3 | 1.52(1.36, 1.70) | < 0.001 | 1.46(1.30, 1.65) | < 0.001 | 1.45(1.28, 1.63) | < 0.001 |
| P for trend | 1.34(1.24, 1.46) | < 0.001 | 1.31(1.20, 1.42) | < 0.001 | 1.3(1.19, 1.41) | < 0.001 |
| METS-IR | 1.02(1.01, 1.03) | 0.001 | 1.03(1.01, 1.04) | < 0.001 | 1.03(1.02, 1.04) | < 0.001 |
| METS-IR tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.14(1.02, 1.28) | 0.024 | 1.2(1.07, 1.34) | 0.002 | 1.21(1.07, 1.35) | 0.002 |
| Q3 | 1.26(1.13, 1.41) | < 0.001 | 1.34(1.19, 1.50) | < 0.001 | 1.35(1.20, 1.51) | < 0.001 |
| P for trend | 1.18(1.09, 1.28) | < 0.001 | 1.23(1.13, 1.33) | < 0.001 | 1.24(1.14, 1.34) | < 0.001 |
| AIP | 1.36(1.17, 1.57) | < 0.001 | 1.41(1.21, 1.63) | < 0.001 | 1.41(1.21, 1.64) | < 0.001 |
| AIP tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.19(1.06, 1.33) | 0.003 | 1.2(1.07, 1.34) | 0.002 | 1.18(1.05, 1.32) | 0.004 |
| Q3 | 1.25(1.11, 1.40) | < 0.001 | 1.28(1.14, 1.43) | < 0.001 | 1.27(1.14, 1.43) | < 0.001 |
| P for trend | 1.17(1.08, 1.27) | < 0.001 | 1.19(1.10, 1.29) | < 0.001 | 1.19(1.09, 1.29) | < 0.001 |
| CTI | 1.21(1.14, 1.29) | < 0.001 | 1.19(1.12, 1.26) | < 0.001 | 1.18(1.11, 1.25) | < 0.001 |
| CTI tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.23(1.09, 1.38) | < 0.001 | 1.19(1.06, 1.33) | 0.004 | 1.17(1.04, 1.31) | 0.008 |
| Q3 | 1.38(1.23, 1.54) | < 0.001 | 1.33(1.19, 1.49) | < 0.001 | 1.3(1.16, 1.46) | < 0.001 |
| P for trend | 1.26(1.16, 1.36) | < 0.001 | 1.22(1.13, 1.32) | < 0.001 | 1.21(1.11, 1.31) | < 0.001 |
| CHG | 1.32(1.17, 1.48) | < 0.001 | 1.29(1.14, 1.45) | < 0.001 | 1.3(1.15, 1.47) | < 0.001 |
| CHG tertile groups | ||||||
| Q1 | Reference | Reference | Reference | |||
| Q2 | 1.19(1.06, 1.33) | 0.004 | 1.18(1.05, 1.33) | 0.004 | 1.17(1.05, 1.32) | 0.007 |
| Q3 | 1.26(1.13, 1.41) | < 0.001 | 1.24(1.11, 1.39) | < 0.001 | 1.25(1.11, 1.40) | < 0.001 |
| P for trend | 1.18(1.09, 1.27) | < 0.001 | 1.17(1.08, 1.26) | < 0.001 | 1.17(1.08, 1.27) | < 0.001 |