Table 6.
Cox regression analysis of IR trajectory markers and cardiovascular disease risk based on ELSA data
| Variables | Model1 | Model2 | Model3 | |||
|---|---|---|---|---|---|---|
| HR(95%CI) | P | HR(95%CI) | P | HR(95%CI) | P | |
| TyG_group | ||||||
| Trajectory 3 | Reference | Reference | Reference | |||
| Trajectory 2 | 1.19(0.91, 1.56) | 0.194 | 1.08(0.83, 1.42) | 0.557 | 1.07(0.82, 1.41) | 0.601 |
| Trajectory 1 | 1.56(1.03, 2.37) | 0.035 | 1.46(0.96, 2.22) | 0.08 | 1.37(0.90, 2.09) | 0.146 |
| P for trend | 1.3(1.02, 1.84) | 0.035 | 1.31(0.97, 1.76) | 0.08 | 1.25(0.93, 1.68) | 0.15 |
| TyG-WC_group | ||||||
| Trajectory 2 | Reference | Reference | Reference | |||
| Trajectory 3 | 1.39(1.04, 1.86) | 0.024 | 1.37(1.02, 1.85) | 0.035 | 1.33(0.99, 1.79) | 0.059 |
| Trajectory 1 | 1.73(1.27, 2.34) | < 0.001 | 1.79(1.30, 2.48) | < 0.001 | 1.67(1.21, 2.32) | 0.002 |
| P for trend | 1.47(1.19, 1.82) | < 0.001 | 1.51(1.20, 1.90) | < 0.001 | 1.44(1.14, 1.81) | 0.002 |
| TyG-WWI_group | ||||||
| Trajectory 3 | Reference | Reference | Reference | |||
| Trajectory 2 | 1.3(0.88, 1.91) | 0.183 | 1.12(0.76, 1.66) | 0.565 | 1.11(0.75, 1.65) | 0.602 |
| Trajectory 1 | 1.88(1.28, 2.76) | 0.001 | 1.36(0.91, 2.04) | 0.129 | 1.31(0.87, 1.96) | 0.191 |
| P for trend | 1.56(1.19, 2.05) | 0.001 | 1.25(0.94, 1.65) | 0.13 | 1.21(0.91, 1.61) | 0.2 |
| TyG-BMI_group | ||||||
| Trajectory 2 | Reference | Reference | Reference | |||
| Trajectory 1 | 1.29(0.99, 1.68) | 0.056 | 1.31(1.00, 1.70) | 0.048 | 1.29(0.99, 1.69) | 0.062 |
| Trajectory 3 | 1.44(1.08, 1.91) | 0.012 | 1.49(1.12, 2.00) | 0.007 | 1.43(1.07, 1.92) | 0.017 |
| P for trend | 1.29(1.06, 1.58) | 0.012 | 1.33(1.08, 1.63) | 0.007 | 1.29(1.05, 1.59) | 0.017 |
| TyG-ABSI_group | ||||||
| Trajectory 3 | Reference | Reference | Reference | |||
| Trajectory 2 | 1.26(0.90, 1.78) | 0.179 | 1.12(0.78, 1.58) | 0.543 | 1.09(0.77, 1.55) | 0.623 |
| Trajectory 1 | 1.61(1.14, 2.28) | 0.007 | 1.27(0.87, 1.85) | 0.218 | 1.22(0.84, 1.78) | 0.299 |
| P for trend | 1.14(1.10, 1.79) | 0.007 | 1.18(0.91, 1.55) | 0.2 | 1.15(0.88, 1.51) | 0.3 |
| TyG-BRI_group | ||||||
| Trajectory 2 | Reference | Reference | Reference | |||
| Trajectory 1 | 1.26(0.96, 1.66) | 0.099 | 1.09(0.82, 1.44) | 0.542 | 1.06(0.80, 1.40) | 0.684 |
| Trajectory 3 | 1.67(1.25, 2.22) | < 0.001 | 1.39(1.04, 1.87) | 0.028 | 1.3(0.97, 1.76) | 0.082 |
| P for trend | 1.44(1.17, 1.76) | < 0.001 | 1.26(1.03, 1.56) | 0.028 | 1.21(0.98, 1.49) | 0.082 |
| TyG-WHtR_group | ||||||
| Trajectory 2 | Reference | Reference | Reference | |||
| Trajectory 1 | 1.26(0.90, 1.78) | 0.179 | 1.12(0.78, 1.58) | 0.543 | 1.09(0.77, 1.55) | 0.623 |
| Trajectory 3 | 1.61(1.14, 2.28) | 0.007 | 1.27(0.87, 1.85) | 0.218 | 1.22(0.84, 1.78) | 0.299 |
| P for trend | 1.4(1.10, 1.79) | 0.007 | 1.18(0.91, 1.55) | 0.2 | 1.15(0.88, 1.51) | 0.3 |
| METS-IR_group | ||||||
| Trajectory 3 | Reference | Reference | Reference | |||
| Trajectory 2 | 1.24(0.95, 1.62) | 0.114 | 1.21(0.92, 1.58) | 0.175 | 1.19(0.91, 1.56) | 0.205 |
| Trajectory 1 | 1.59(1.20, 2.10) | 0.001 | 1.6(1.20, 2.14) | 0.001 | 1.54(1.15, 2.06) | 0.003 |
| P for trend | 1.39(1.14, 1.69) | 0.001 | 1.4(1.14, 1.71) | 0.001 | 1.36(1.11, 1.67) | 0.003 |
| AIP_group | ||||||
| Trajectory 3 | Reference | Reference | Reference | |||
| Trajectory 2 | 1.39(1.04, 1.85) | 0.026 | 1.28(0.96, 1.71) | 0.099 | 1.28(0.95, 1.71) | 0.1 |
| Trajectory 1 | 1.67(1.13, 2.49) | 0.011 | 1.6(1.07, 2.40) | 0.021 | 1.56(1.04, 2.33) | 0.031 |
| P for trend | 1.44(1.09, 1.90) | 0.011 | 1.4(1.05, 1.86) | 0.021 | 1.37(1.03, 1.82) | 0.031 |
| CTI_group | ||||||
| Trajectory 3 | Reference | Reference | Reference | |||
| Trajectory 2 | 1.8(1.26, 2.56) | 0.001 | 1.53(1.07, 2.18) | 0.021 | 1.47(1.03, 2.11) | 0.034 |
| Trajectory 1 | 2.45(1.63, 3.69) | < 0.001 | 2(1.31, 3.04) | 0.001 | 1.9(1.25, 2.89) | 0.003 |
| P for trend | 1.89(1.41, 2.52) | < 0.001 | 1.63(1.21, 2.20) | 0.001 | 1.57(1.17, 2.12) | 0.003 |
| CHG_group | ||||||
| Trajectory 3 | Reference | Reference | Reference | |||
| Trajectory 2 | 1(0.74, 1.35) | 0.988 | 0.97(0.71, 1.31) | 0.818 | 0.98(0.73, 1.33) | 0.912 |
| Trajectory 1 | 1.08(0.79, 1.47) | 0.647 | 1.03(0.75, 1.42) | 0.855 | 1.06(0.77, 1.46) | 0.721 |
| P for trend | 1.05(0.84, 1.31) | 0.6 | 1.02(0.82, 1.28) | 0.9 | 1.04(0.83, 1.31) | 0.7 |