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. 2026 Aug 26;17:1844013. doi: 10.3389/fphar.2026.1844013

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Copyright © 2026 Chen, Han, Zhang, Cao and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Western blot image showing protein expression levels of signaling and apoptosis-related proteins under different treatment conditions. Bands are labeled for proteins such as P-PI3K, PI3K, P-Akt, Akt, P-mTOR, mTOR, Bax, Bcl-2, Bcl-XL, Caspase-3, Cleaved Caspase-3, PARP, and Cleaved PARP, with loading controls including α-tubulin, GAPDH, and β-actin. Treatment groups involve combinations of HSP90AA1, Trastuzumab, Lapatinib, and Tanespimycin compared to control, with plus and minus symbols indicating presence or absence of each compound. — Western blot analysis assessing the expression and phosphorylation of PI3K, Akt, and mTOR, along with key Apoptotic markers in different treatment groups.