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Amino Acid Alignment of SOS2 with PKS2 to PKS8.
The N-terminal kinase catalytic domain is highly conserved. The C-terminal regulatory domain contains the conserved FISL motif (marked). Also marked is the activation loop between the conserved DFG and APE motifs (dots) and the Thr residue, which may be phosphorylated by an upstream protein kinase (asterisk). Dashed lines represent spaces that were introduced to maximize alignment.
