Fig. 2. Modulation of H2AJ regulates malignant properties of LUAD cells.

A, B Results of invasion and proliferation assays after ectopic H2AJ overexpression (A) and knockdown (B) in A549 cells. C, D Invasion and proliferation assay results following ectopic H2AJ overexpression (C) and knockdown (D) in A427 cells. E Luminescence signals of A549 cells in lungs of mice following intravenous injection (5 mice each group). F Luminescence signals of A549 cells in lungs of mice after sacrifice. G Metastatic nodules in lungs of mice after sacrifice (P = 2.2 × 10−3). H Hematoxylin and eosin (H&E) staining of lung tissues. **P < 0.01, ***P < 0.001 vs control. Scale bar = 200 μm.