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. 2026 Jun 26;17(1):791. doi: 10.1038/s41419-026-09054-9

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A, B Volcano plot (A) and PCA plot (B) of RNA-seq data following ectopic H2AJ overexpression in A549 cells. C Heatmap of the DEGs (497 genes are upregulated, 428 genes are downregulated, FDR < 0.05). D Gene set enrichment analysis (GSEA) of RNA-seq data following ectopic H2AJ overexpression in A549 cells.