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. 2026 Jun 26;17(1):791. doi: 10.1038/s41419-026-09054-9

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Genomic distribution of anti-Flag ChIP-Seq peaks in H2AJ overexpressing A549 cells. Promoter indicates 3 kb regions upstream and downstream of the TSSs. Intergenic refers to regions larger than 3 kb from TSS or TTS. B Association of H2A.J peaks with various histone markers. Data are shown as the number of H2A.J binding summits overlapping the peak regions of these histone marks. C ENCODE histone ChIP-Seq signal profiles in the H2A.J binding summit region. D, E Heatmaps and violin plots of H3K27me3 (D) and H3K9me3 (E) ChIP-Seq signal profiles at the H2A.J binding summit region in control or H2AJ overexpressing A549 cells. F Immunoblot validation of Flag-H2A.J, H3K27me3 and H3K9me3 after ectopic Flag-H2AJ overexpression in A549 cells. G, H Flag-H2A.J, H3K27me3, and H3K9me3 ChIP-Seq read distribution profiles (G) and heatmaps (H) of three gene groups classified by their expression levels (red: high-expression group, green: intermediate-expression group, and blue: low-expression group, n = 5565, 5567, and 3260 genes).