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. 2026 Jun 26;17(1):791. doi: 10.1038/s41419-026-09054-9

Fig. 6. TMEM158 is associated with LUAD malignant properties.

Fig. 6

A Comparison of TMEM158 expression in normal and tumor tissues of patients with LUAD (P = 2.7 × 10−2 for GSE31210 and 6.3 × 10−7 for GSE10072, t-test) and overall survival rates of these patients classified by TMEM158 expression (P = 1.8 × 10−4 for GSE31210 and 6.9 × 10−4 for GSE50081, log-rank test). B, C Results of immunoblot validation, invasion, and proliferation assay after ectopic TMEM158 overexpression (B) and knockdown (C) in A549 cells. Upper band is Flag-tagged TMEM158 proteins and lower band is endogenous proteins (black triangle). Scale bar = 200 μm. D Correlation of H2AJ and TMEM158 expression (P = 2.8 × 10−8 for GSE31210 and 3.9 × 10−2 for GSE10072, Spearman’s rank correlation coefficient). E Overall survival of LUAD patient groups stratified by H2AJ and TMEM158. The number of patients (n) in each subgroup (H2AJ-high/TMEM158-low, H2AJ-low/TMEM158-low, H2AJ-high/TMEM158-high, and H2AJ-low/TMEM158-high) is indicated for the GSE50081 (n = 55, 23, 28, 21) and GSE31210 (n = 80, 29, 39, 56), respectively. Error bars show the mean ± standard error of the mean (SEM) of 3 biological replicates, *P < 0.05, ***P < 0.001 vs control.