FIG. 1.

apoJ/clusterin-deficient mice develop glomerulopathy. Representative glomeruli are shown from a single kidney of a 21-month-old mouse to illustrate the range of affected structures and the basis of a glomerular lesion scoring system. The different panels represent scores of 0 to 4, based on the extent of expansion of the mesangium by hypocellular material, where 0 = normal, 1 = change affecting less than 25% of the glomerulus, 2 = change affecting 25 to 50%, 3 = change affecting 50 to 75%, and 4 = changes affecting greater than 75%. Magnification, ×400.