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apoJ/clusterin protects the kidney from deposition of preassembled immunoglobulin complexes in the glomerulus. Phase contrast microscopy (A and C) shows comparable glomerular fields, which upon indirect fluorescence (B and D) exhibit strongly different distributions of Texas Red-labeled sheep anti-goat IgG complexes. Wild-type animals do not show any glomerular accumulation, whereas apoJ/clusterin-deficient mice do, in a patchy mesangial distribution.
