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. 2026 Aug 27;15(8):585. doi: 10.21037/tcr-2026-1405

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Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Validation of the prognostic model associated with PMNPs. Visualization of risk score distribution and survival status within the GSE71729 (A) and ICGC cohort (F). Kaplan-Meier curves of patients with low and high PMNPs score in GSE71729 (B) and ICGC cohort (G). Time-dependent ROC curves of the signature for overall survival rates at 1 and 3 years in the GSE71729 (C) and ICGC cohort (H). The DCA curve revealed the clinical net benefit of the constructed model in the GSE71729 (D,E) and ICGC cohort (I,J). AUC, area under the curve; DCA, decision curve analysis; FPR, false positive rate; HR, hazard ratio; ICGC, International Cancer Genome Consortium; MNPs, microplastics and nanoplastics; PAAD, pancreatic ductal adenocarcinoma; PMNPs, MNPs-related genes in PAAD; ROC, receiver operating characteristic; TPR, true positive rate.