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. 2006 Jan 15;20(2):210–224. doi: 10.1101/gad.1380406

Figure 2.

Figure 2.

ORF2p translation starts at the first in-frame AUG codon of ORF2. The schematic depicts cartoons of each of the mutant constructs tested in the retrotransposition assay. The red asterisks signify the two stop codons in the inter-ORF spacer. The relative position of each mutation is shown below the cartoons. The construct names are indicated in the left column, and representative data from the cultured cell retrotransposition assay are indicated at the right of the figure. The relative retrotransposition efficiency is indicated in the parenthesis and is compared with the relative retrotransposition efficiency of the wild-type control (RA101). RA105 is a retrotransposition-defective L1 containing a missense mutation in the RT active site (Moran et al. 1996; Wei et al. 2001). JM111/L1.3 is a retrotransposition-defective L1 containing a pair of missense mutations in ORF1 (Moran et al. 1996; Wei et al. 2001).