Table 1.

Functional associations between components of RefSeq transcriptional chimeras supported by ESTs

		No. RT-PCR positives	Physical associationa		Functional associationb		Related gene fusionsc
Chimera	No. ESTs		Same/orth.	COG	Same/orth.	COG	Fusion	Organism
NME1–NME2	4	7	Yes	Yes	TXN-NDK(3)	HS, MM
NDK-DSCAML1	MM
ELA3A–ELA3B	1	—	Yes	Yes	SMO/FZD-Trypsin like	HS
Fibrillin-trypsin like	HS
Scavenger receptor-trypsin like	HS
BHMT2–BHMT	1	—	Yes	Yes	BHMT-Methionine synthase	HS, MM, CE
ACAD10–ALDH2	1	1	No	Yes	No	Yes	ALDH-ADH	Prokaryotes
PRODH-ALDH	Prokaryotes
HAD-APH-ACAD	HS, MM, CE
ASL–RCP9	1	—	No	Yes	No	Yes	NAD oxidoreductase-RPC17	CE
GIMAP2–GIMAP1	1	No	No	Yes
PLCXD2–PHLDB2	2	1	No	No	Yes
DTX2–PMS2L5	2	1	No	Yes	No	Yes	5′–3′ exonuclease-helicase	Prokaryotes
SENP3–EIF4A1	1	—	No	Yes	No	Yes
HIF1A–SNAPC1	1	—	No	No	No	Yes
MIA–RAB4B	1	—	No	No	No	Yes
SLC2A11–MIF	1	—	No	No	No	Yes	MIF-PGLYRP	MM
HSPH1–PREI3	2	1	No	No	No	Yes
SNTB2–VPS4A	1	—	No	No	No	Yes
ATP6V0C–CGI-14	1	—	No	No	No	Yes
TMPIT–STYXL1	2	2	No	No	No	Yes
FPGT–TNNI3K	3	4	No	No	No	Yes

^aPhysical interactions between components or their orthologs (Same/orth.) or proteins within Clusters of Orthologous Sequences (COG) were retrieved from BIND databases (http://bind.ca/). These associations can be either direct, or as part of multi-subunit complexes. For interactions for which only yeast two-hybrid data are available, only those with high-confidence were considered

^bFunctional associations between chimera components or proteins within COGs were inferred from the STRING server (http://string.embl.de/) and from the KEGG metabolic pathways database

^cPreviously described fusions involving one of the two partners of the tandem chimeras are shown on the first column. Information for gene fusions was retrieved from STRING (http://string.embl.de/). (HS) Homo sapiens; (MM) Mus musculus; (CE) Caenorhabditis elegans