Table 3.

Categorization of the 109 Sanger chr22 genes without equivalents in our data set

Reason for lack of a known gene or TU corresponding to a Sanger gene	No. of Sanger genes
Unknown; Sanger gene passes GSPS and LOCUS criteria	11
Sanger gene is transcriptionally silent,a but not in a recent duplication	34
Sanger gene is putatively transcriptionally silent,b and in a recent duplication	35
Sanger gene is homologous to immunoglobulin gene segments	9
Sanger gene is transcribed, but as an unspliced nonpolyadenylated singleton	19
Special case	1

^aTranscriptionally silent: no public ESTs or flcDNAs overlap any exons of the Sanger gene model on the sense strand of that model

^bPutatively transcriptionally silent: the Sanger gene model is in a recent paralogous segmental duplication. Some public ESTs and/or flcDNAs have high sense-strand homologies to the Sanger gene model. However, these ESTs/cDNAs match another copy of the duplicated region better than they match the copy containing the Sanger gene model being considered. Therefore, the Sanger model is most likely transcriptionally silent