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Illustration of the regulation of hypoxia-inducible genes. Under hypoxic conditions, the accumulation of HIF-1a was accompanied by an elevation of intercellular calcium. HIF-1 directly transactivates hypoxia-inducible genes. Ca activates the JNK/AP-1 pathway, which contributes to transactivation, and potentially may participate in the stabilization of the mRNA of hypoxia-inducible genes.
