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. 2005 Nov;12(6):557–563. doi: 10.1101/lm.28105

Figure 2.

Figure 2.

Acquisition of eyelid CRs in control and MSDB-lesioned rats. (A) A trace-conditioning paradigm was used to evaluate putative learning deficits in animals with a specific lesion of cholinergic neurons located in the MSDB complex. Learning curves of saline-injected rats (white circles, n = 10), 192-IgG-saporin-injected rats (black circles, n = 10), and pseudoconditioned animals (gray circles, n = 4). Because results obtained with 192IgG-saporin-injected rats during both pseudoconditioning and conditioning programs were similar, the pseudoconditioning curve has been omitted for the sake of clarity. (B) Selective cholinergic MSDB lesions did not affect the retrieval of previously acquired eyelid CRs. Retention index: percentage of CRs during the test session/percentage of CRs during the last conditioning session. White bar, saline-injected rats; black bar, 192-IgG-saporin-injected rats (n = 8 per group). Pseudocond, pseudoconditioning saline-injected rats; *, significant differences between saline- or 192IgG-saporin-injected conditioned groups with respect to pseudoconditioned saline-injected groups; +, significant difference between saline- and 192IgG-saporin-injected groups. *, +, P ≤ 0.05; **, ++, P ≤ 0.01; ***, +++, P ≤ 0.001.