Table 2.

Multivariate analysis for the prediction of the composite secondary endpoint (all-cause mortality, myocardial infarction, stroke, or major bleeding)

Predictor	HR (95% CI)	p-value
Myocardial revascularization	0.89 (0.85–0.96)	0.001
Age per 1 year (y)	1.04 (1.01–1.08)	< 0.05
Female gender	0.72 (0.44–1.17)	0.181
Serum creatinine (per 0.1 mg/dL)	1.04 (1.01–1.06)	< 0.0001
NT-proBNP (per 1000 ng/L)	1.1 (1.02–1.19)	< 0.05
GRACE 2.0-score (per 10‑point increase)	1.55 (1.18–2.13)	0.002
History of CAD	0.76 (0.44–1.32)	0.301
Prior MI	1.41 (1.12–1.87)	< 0.05
History of PAD	1.11 (0.57–2.22)	0.765
Active or ex-smoker	1.16 (1.04–1.28)	0.006
Arterial hypertension	1.45 (1.12–1.87)	0.003
Hypercholesterolemia	1.16 (1.1–1.28)	0.027
Diabetes mellitus	1.02 (0.74–1.42)	0.892

Hazard ratios (HR) with 95% confidence intervals and p-values for predictors of death, myocardial infarction, stroke, or major bleeding in the full cohort of AF patients meeting ESC rule-in criteria

CAD coronary artery disease, CI confidence interval, HR hazard ratio, MI myocardial infarction, PAD peripheral artery disease