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Targeted disruption of the Chk2 gene in mice. (A) Targeting strategy. The genomic configuration of the germ line Chk2 locus is shown at the top. The targeting vector is shown in the center; exons 8 to 11 were replaced with a neomycin cassette (Neo). The mutated Chk2 locus is shown at the bottom. (B) Western blot showing the expression of Chk2 and β-actin proteins in various tissues of wild-type (Wild) and Chk2−/− mice.
