FIGURE 8. Potential model illustrates the activation of NF-κB transcription factor and induction of NF-κB-dependent genes in esophageal adenocarcinoma. Stimuli such as bile acids, low pH, cytokines, radiation and cytotoxic drugs induce NF-κB, which subsequently regulates many genes involved in cell proliferation, cytokine production, cell adhesion and apoptosis.