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. 2005 Nov 10;24(23):4018–4028. doi: 10.1038/sj.emboj.7600863

Figure 5.

Figure 5

SIKE inhibits VSV-induced and RIG-I-mediated activation of ISRE (A) and the IFN-β promoter (B) but not NF-κB (C). The 293 cells (1 × 105) were transfected with the indicated luciferase reporter plasmid (0.1 μg), an empty control vector or an expression plasmid for RIG-I (1 μg) as indicated, and an empty control vector (empty bars) or an expression plasmid for SIKE (filled bars). At 14 h after transfection, cells were infected with VSV or left infected for 18 h before luciferase assays were performed.