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. 2005 Dec 1;24(24):4345–4355. doi: 10.1038/sj.emboj.7600896

Figure 6.

Figure 6

A model for ATL-1 activation in response to replication fork stalling and following processing of DSBs. (A) RPA-ssDNA complexes generated following replication fork pausing/stalling following hydroxyurea (HU) treatment recruit ATL-1. ATL-1 and RAD-5/CLK-2 are both required to stabilize stalled replication forks and to activate the S-phase checkpoint to transiently arrest the cell cycle to provide time to restart DNA synthesis. (B) MRE-11 is recruited to DSBs generated following IR-treatment. Once recruited, MRE-11 is believed to recruit ATM-1 based on studies in mammalian cells and also regulates DSB processing. RPA-ssDNA complexes generated by DSB resection recruit ATL-1. Together, ATL-1, RAD-5/CLK-2 and ATM-1 cooperate to induce cell cycle arrest or apoptosis via the cep-1/egl-1 pathway.